Research supporting cognitive reserve theory suggests that engaging in a variety of cognitive, social, and physical activities may serve as protective factors against age-related changes in mental functioning, especially if the activities are cognitively engaging. Individuals who participate in a variety of cognitive activities have been found to be more likely to maintain a higher level of cognitive functioning and be less likely to develop dementia. In this study, we explore the relationship between engaging in a variety of activities and (...) cognitive performance amongst 206 healthy older adults between the ages of 65–85. Age and years of education were found to be the most significant predictors of a global composite representing cognitive performance, consistent with previous work linking these variables to age-related changes in cognition and the cognitive reserve. We interpret these results to suggest that age and education are better predictors of global cognitive performance in older adults than self-reported activity engagement. (shrink)

This volume examines some of the most contentious social justice issues present in the corpus of Augustine's writings. Whether one is concerned with human trafficking and the contemporary slave trade, the global economy, or endless wars, these essays further the conversation on social justice as informed by the writings of Augustine of Hippo.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Behaving consistently across situations is fundamental to a person’s authenticity in Western societies. This can pose a problem for biculturals who often frame switch, or adapt their behavior across cultural contexts, as a way of maintaining fit with each of their cultures. In particular, the behavioral inconsistency entailed in frame switching may undermine biculturals’ sense of authenticity, as well as Westerners’ impressions of biculturals’ authenticity. Study 1 had a diverse sample of biculturals (N = 127) living in the US and (...) Canada describe an episode of frame switching (vs. no switching control vs. neutral control) and report on their state authenticity during the episode. Results showed that biculturals recalled feeling less authentic during an instance of frame switching compared to no switching control and neutral control. Study 2 had mainstream Canadians (White and of American, Canadian, or Western European cultural heritage, N = 97) read a hypothetical vignette, from a third-person perspective, about a bicultural who frame switches (vs. no switching control vs. neutral control) and provide their impressions of the bicultural’s authenticity and multiple other desirable traits. Participants rated the bicultural as less authentic when he frame switched compared to no switching control and neutral control, and rated him as less likeable, trustworthy, and warm (but not competent) as downstream consequences of seeing him as less authentic. These results demonstrate that frame switching can come at a cost to authenticity, both in terms of how biculturals see themselves and are seen by others, at least in Western societies. These findings highlight that the way biculturals negotiate their cultures affects them psychologically and socially. In the context of cultural fit, the active process of establishing and maintaining fit with one’s cultures can have unforeseen consequences. (shrink)

Scientists and historians have often presumed that the divide between biochemistry and molecular biology is fundamentally epistemological.100 The historiography of molecular biology as promulgated by Max Delbrück's phage disciples similarly emphasizes inherent differences between the archaic tradition of biochemistry and the approach of phage geneticists, the ur molecular biologists. A historical analysis of the development of both disciplines at Berkeley mitigates against accepting predestined differences, and underscores the similarities between the postwar development of biochemistry and the emergence of molecular biology (...) as a university discipline. Stanley's image of postwar biochemistry, with its focus on viruses as key experimental systems, and its preference for following macromolecular structure over metabolism pathways, traced the outline of molecular biology in 1950.Changes in the postwar political economy of research universities enabled the proliferation of disciplines such as microbiology, biochemistry, biophysics, immunology, and molecular biology in universities rather than in medical schools and agricultural colleges. These disciplines were predominantly concerned with investigating life at the subcellular level-research that during the 1930s had often entailed collaboration with physicists and chemists. The interdisciplinary efforts of the 1930s (many fostered by the Rockefeller Foundation) yielded a host of new tools and reagents that were standardized and mass-produced for laboratories after World War II. This commercial infrastructure enabled “basic” researchers in biochemistry and molecular biology in the 1950s and 1960s to become more independent from physics and chemistry (although they were practicing a physicochemical biology), as well as from the agricultural and medical schools that had previously housed or sponsored such research. In turn, the disciplines increasingly required their practitioners to have specialized graduate training, rather than admitting interlopers from the physical sciences.These general transitions toward greater autonomy for biochemistry and allied disciplines should not mask the important particularities of these developments on each campus. At the University of Caliornia at Berkeley, agriculture had provided, with medicine, significant sponsorship for biochemistry. The proximity of Lawrence and his cyclotrons supported the early development of Berkeley as a center for the biological uses of radioisotopes, particularly in studies of metabolism and photosynthesis. Stanley arrived to establish his department and virus institute before large-scale federal funding of biomedical research was in place, and he courted the state of California for substantial backing by promising both national prominence in the life sciences and virus research pertinent to agriculture and public health. Stanley's venture benefited significantly from the expansion of California's economy after World War II, and his mobilization against viral diseases resonated with the concerns of the Cold War, which fueled the state's rapid growth. The scientific prominence of contemporary developments at Caltech and Stanford invites the historical examination of the significance of postwar biochemistry and molecular biology within the political and cultural economy of the Golden State.In 1950, Stanley presented a persuasive picture of the power of biochemistry to refurbish life science at Berkeley while answering fundamental questions about life and infection. In the words of one Rockefeller Foundation officer,There seems little doubt in [my] mind that as a personality Stanley will be well able to dominate the other personalities on the Berkeley campus and will be able to drive his dream through to completion, which, incidentally, leaves Dr. Hubert [sic] Evans and the whole ineffective Life Sciences building in the somewhat peculiar position of being by-passed by much of the truly modern biochemistry and biophysics research that will be carried out at Berkeley. Furthermore, it seems likely that Dr. S's show will throw Dr. John Lawrence's Biophysics Department strongly in the shade both figuratively and literally, but should make the University of California pre-eminent not only in physics but in biochemistry as well.101Stanley, Sproul, Weaver, and this officer (William Loomis) all testified to a perceptible postwar opportunity to capitalize on public support for biological research that relied on the technologies from physics and chemistry without being captive to them, and that addressed issues of medicine and agriculture without being institutionally subservient. What is striking, given the expectation by many that Stanley would ‘be able to drive his dream through to completion,” was that in fact he did not. Biochemists who had succeeded in making their expertise valued in specialized niches were resistant to giving up their affiliations to joint Stanley's “liberated” organization. Stanley's failure was not simply due to institutional factors: researchers as well as Rockefeller Foundation officers faulted him for his lack of scientific imagination, which made it difficult for him to gain credibility in leading the field. Moreover, many biochemists did not share Stanley's commitment to viruses as the key material for the “new biochemistry.”In the end, Stanley's free-standing department did become a first-rate department of biochemistry, but only after freeing itself from Stanley's leadership and his single-minded devotion to viruses. Nonetheless, the falling-out with the Berkeley biochemists was rapidly followed by the establishment of a Department of Molecular Biology, attesting to the unabating economic and institutional possibilities for an authoritative “general biology” (or two, for that matter) to take hold. In each case, following Stanley's dream sheds light on how the possible and the real shaped the (re)formation of biochemistry and molecular biology as postwar life sciences. (shrink)

It was a characteristic of Macedonian custom that a name was used in a special and in a general sense. For example, ‘Foot-Companions’ was the name of a Bodyguard of Philip and also of the men of the Phalanx-Brigades from Lower Macedonia, and ‘Hypaspists’ was the name of Infantry-Guardsmen of Alexander and also of the men of three Hypaspist Phalanx-Brigades. Geographical names were repeated: there were at least two regions and two cities called ‘Emathia’, two or three regions called ‘Doberus’, (...) four cites called Philippi or Philippopolis, and Alexandrias galore. To a modern mind this makes for confusion. That is certainly the case with the names ‘Macedonia’ and ‘Macedones’, which I shall treat separately in this article. (shrink)

A reconstruction of the medical instruction of the iatrosophists in Alexandria (5th–7th century) faces serious problems, because the sources provide us with no information on either their organisation or the biographies of their teachers. Nonetheless, some key points can be established that were characteristic of the teaching of the iatrosophists. These include the medical curriculum, the textbooks used, the type of lectures, the practical training, and the teaching units on philosophical themes. Further, it seems that Gessius initiated this type (...) of teaching, and in the process made numerous borrowings especially from his philosophy teacher Ammonius. Ultimately, the rise in the teaching of the iatrosophists can be explained by different innovations in educational politics that can also be detected in other parts of the Roman Empire at the same time. (shrink)

Many philosophers hypothesize that our concept of personal identity is partly constituted by the one-person-one-place rule, which states that a person can only be in one place at a time. This hypothesis has been assumed by the most influential contemporary work on personal identity. In this paper, we report a series of studies testing whether the hypothesis is true. In these studies, people consistently judged that the same person existed in two different places at the same time. This result undermines (...) some widely held philosophical assumptions, supports others, and fits well with recent discoveries on identity judgments about inanimate objects and non-human animals. (shrink)

In an attempt to improve upon Alexander Pruss’s work (The principle of sufficient reason: A reassessment, pp. 240–248, 2006), I (Weaver, Synthese 184(3):299–317, 2012) have argued that if all purely contingent events could be caused and something like a Lewisian analysis of causation is true (per, Lewis’s, Causation as influence, reprinted in: Collins, Hall and paul. Causation and counterfactuals, 2004), then all purely contingent events have causes. I dubbed the derivation of the universality of causation the “Lewisian argument”. The (...) Lewisian argument assumed not a few controversial metaphysical theses, particularly essentialism, an incommunicable-property view of essences (per Plantinga’s, Actualism and possible worlds, reprinted in: Davidson (ed.) Essays in the metaphysics of modality, 2003), and the idea that counterfactual dependence is necessary for causation. There are, of course, substantial objections to such theses. While I think a fight against objections to the Lewisian argument can be won, I develop, in what follows, a much more intuitive argument for the universality of causation which takes as its inspiration a result from Frederic B. Fitch’s work (J Symb Logic 28(2):135–142, 1963) [with credit to who we now know was Alonzo church’s, Referee Reports on Fitch’s Definition of value, in: (Salerno (ed.), New essays on the knowability paradox, 2009)] that if all truths are such that they are knowable, then (counter-intuitively) all truths are known. The resulting Church–Fitch proof for the universality of causation is preferable to the Lewisian argument since it rests upon far weaker formal and metaphysical assumptions than those of the Lewisian argument. (shrink)

Episodic memory has a distinctive phenomenology: it involves “mentally reliving” a past event. It has been suggested that characterising episodic memory in terms of this phenomenology makes it impossible to test for in animals, because “purely phenomenological features” cannot be detected in animal behaviour. Against this, I argue that episodic memory's phenomenological features are impure, having both subjective and objective aspects, and so can be behaviourally detected. Insisting on a phenomenological characterisation of episodic memory consequently does nothing to damage the (...) prospects for detecting it in nonhuman animals. (shrink)

Episodic memory is the form of memory involved in remembering personally experienced past events. Here, I address two questions about episodic memory’s function: what does episodic memory do for us, and why do we have it? Recent work addressing these questions has emphasized episodic memory’s role in imaginative simulation, criticizing the mnemonic view on which episodic memory is “for” remembering. In this paper, I offer a defense of the mnemonic view by highlighting an underexplored mnemonic function of episodic memory – (...) namely, its role in the encoding, storage and retrieval of the type of information more standardly associated with semantic memory. I argue that in healthy individuals, episodic memory plays a central role in the encoding, storage and retrieval of prototypically semantic information, analogous to the role played by mind palaces in the method of loci, and may have been selected on for this reason. This suggests new directions for studying episodic memory, particularly in nonhuman animals. (shrink)

Episodic memory is memory for past events. It’s characteristically associated with an experience of ‘mentally replaying’ one’s experiences in the mind’s eye. This biological phenomenon has inspired the development of several ‘experience replay’ algorithms in AI. In this chapter, I ask whether experience replay algorithms might shed light on a puzzle about episodic memory’s function: what does episodic memory contribute to the cognitive systems in which it is found? I argue that experience replay algorithms can serve as idealized models of (...) episodic memory for the purposes of addressing this question. Taking the DQN algorithm as a case study, I suggest that these algorithms provide some support for mnemonic accounts, on which episodic memory’s function lies in the storage, encoding and retrieval of information. By extending and adapting experience replay algorithms, we might gain further insight into episodic memory’s operations and contributions to cognition. (shrink)

In dicephalus conjoined twinning, it appears that two heads share a body; in cephalopagus, it appears that two bodies share a head. How many human animals are present in these cases? One answer is that there are two in both cases—conjoined twins are precisely that, conjoined twins. Another is that the number of humans corresponds to the number of bodies—so there is one in dicephalus and two in cephalopagus. I show that both of these answers are incorrect. Prominent accounts of (...) biological individuation, which treat the organism as an integrated whole, reveal that in these and other cases of conjoined twinning the ‘twins’ share a single human animal. This has a number of consequences for the debate about what we are. First, if animalism is true, individuals of our kind can be—and are—profoundly psychologically divided. Second, cephalopagus twinning does not divide animalism from its rivals, as has been claimed. Finally, animalists can reply to a vicious species of the ‘too many thinkers’ problem to which they are allegedly uniquely vulnerable. (shrink)

Episodic memory—memory for personally experienced past events—seems to afford a distinctive kind of cognitive contact with the past. This makes it natural to think that episodic memory is centrally involved in our understanding of what it is for something to be in the past, or to be located in time—that it is either necessary or sufficient for such understanding. If this were the case, it would suggest certain straightforward evidential connections between temporal cognition and episodic memory in nonhuman animals. In (...) this paper, I argue that matters are more complicated than this. Episodic memory is memory for events and not for the times they occupy. As such, it is dissociable from temporal understanding. This is not to say that episodic memory and temporal cognition are unrelated, but that the relationship between them cannot be straightforwardly captured by claims about necessity and sufficiency. This should inform our theoretical predictions about the manifestations of episodic memory in nonhuman behaviour. (shrink)

Contemporary Roman Catholic ethics endeavors to take sin seriously by offering theologies of sin that emphasize it as a force and as a basic, personal orientation. Such efforts rightly counter the Catholic tradition's earlier reduction of sin to sins, and sins to external acts and moral culpability. But perhaps they go too far in this regard. By engaging Charles Curran, this study argues that inattention to sins undermines the theological referent of sin as a discourse that concerns more than moral (...) culpability, obscures God as the source of freedom and value, and neglects the way in which acts express and sustain sin and fashion a personal orientation. Drawing on the work of Jean Porter, the essay shows that attention to sins highlights the historicity, particularity, and provisionality of human acts because of the theological referent and analogical character of sin and sins. (shrink)

The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary prior to their transcription. Their expression is regulated both temporally and spatially within this tissue. They thus serve as models both for the regulation of DNA replication and of developmental transcription. The regulatory elements for DNA amplification have been delineated. Their analysis reveals that amplification is mediated by several regulatory regions and initiates at defined origins within the chorion cluster. Proteins involved (...) in amplification are being identified both by mutations affecting amplification and by DNA binding studies. Regulatory elements for temporal as well as spatial control of chorion gene, expression have been characterized, and two candidate transcription factor genes have been cloned. (shrink)

Replications are often taken to play both epistemic and demarcating roles in science: they provide evidence about the reliability of fields’ methods and, by extension, about which fields “count” as scientific. I argue that, in a field characterized by a high degree of theoretical openness and uncertainty, like comparative cognition, replications do not sit well in these roles. Like other experiments conducted under conditions of uncertainty, replications are often equivocal and open to interpretation. As a result, they are poorly placed (...) to deliver clear judgments about the reliability of comparative cognition’s methods or its scientific bona fides. I suggest that this should encourage us to take a broader view of both the nature of scientific progress and the role of replication in comparative cognition. (shrink)

Mindreaders can ascribe representational states to others. Some can ascribe representational states – states with semantic properties like accuracy-aptness. I argue that within this group of mindreaders, there is substantial room for variation – since mindreaders might differ with respect to the representational format they take representational states to have. Given that formats differ in their formal features and expressive power, the format one takes mental states to have will significantly affect the range of mental state attributions one can make, (...) and the ease or difficulty with which one can make them. I illustrate this by considering what it would be to take mental states to be map-like in format, showing that this would result in a distinctively limited form of mindreading. I close by articulating the significance of this for the emerging picture of great ape mindreading. (shrink)

Comparative cognitive science often involves asking questions like ‘Do nonhumans have C?’ where C is a capacity we take humans to have. These questions frequently generate unproductive disagreements, in which one party affirms and the other denies that nonhumans have the relevant capacity on the basis of the same evidence. I argue that these questions can be productively understood as questions about natural kinds: do nonhuman capacities fall into the same natural kinds as our own? Understanding such questions in this (...) way has several advantages: it preserves the intuition that these are substantive empirical questions worth asking; it helps us to understand why they so frequently give rise to disagreements of the kind described; and it provides clues about how to diagnose and resolve them. (shrink)

After an introduction which demonstrates the failure of the equational analogue of Beth?s definability theorem, the first two sections of this paper are devoted to an elementary exposition of a proof that a functional constant is equationally definable in an equational theory iff every model of the set of those consequences of the theory that do not contain the functional constant is uniquely extendible to a model of the theory itself.Sections three, four and five are devoted to applications and extensions (...) of this result.Topics considered here include equational definability in first order logic, an extended notion of definability in equational logic and the synonymy of equational theories.The final two sections briefly review some of the history of equational logic. (shrink)

Pacifism is routinely criticized as sectarian, incoherent, and preoccupied with moral purity at the expense of responsibility. The author contends that the pacifism of John Howard Yoder is vulnerable to none of these charges and defends this claim by establishing parallels between Yoder's analysis of killing and Augustine's analysis of lying. Although, within the terms of his own argument, Augustine's rejection of all lying as unjust is consistent with his condoning of some killing as just, the author shows that given (...) a different conception of the defining characteristic of God , Augustine's theological argument against lying would become an argument against violence. The author therefore suggests that Yoder's rejection of killing is no more sectarian, incoherent, or irresponsible than Augustine's rejection of lying. (shrink)

We argue that there exists a necessary causally potent being. We then argue that that being is God.

Research suggests that metacognitive monitoring ability does not decline with age. For example, judgments-of-learning accuracy is roughly equivalent between younger and older adults. But few studies have asked whether younger and older adults’ metacognitive ability varies across different types of memory processes. The current study tested the relationship between memory and post-decision confidence ratings at the trial level on item and associative memory recognition tests. As predicted, younger and older adults had similarmetacognitive efficiency, when using meta-d’/d’, a measure derived from (...) Signal Detection Theory, despite a significant age effect favoring younger adults on memory performance. This result is consistent with previous work showing age-equivalent metacognitive efficiency in the memory domain. We also found that metacognitive efficiency was higher for associative memory than for item memory across age groups, even though associative and item recognition memory were statistically equivalent. Higher accuracy on post-test decision confidence ratings for associative recognition relative to item recognition on resolution accuracy itself and when corrected for performance differences are novel findings. Implications for associative metacognition are discussed. (shrink)

That great apes are the only primates to recognise their reflections is often taken to show that they are self-aware—however, there has been much recent debate about whether the self-awareness in question is psychological or bodily self-awareness. This paper argues that whilst self-recognition does not require psychological self-awareness, to claim that it requires only bodily self-awareness would leave something out. That is that self-recognition requires ‘objective self-awareness’—the capacity for first person thoughts like ‘that's me’, which involve self-identification and so are (...) vulnerable to error through misidentification. This objective self-awareness is distinct from bodily or psychological self-awareness, requires cognitive sophistication and provides the beginnings of a more conceptual self-representation which might play a role in planning, mental time travel and theory of mind. (shrink)

Debates over physician-assisted suicide comprise a small portion of broader culture wars. Their role in the culture wars obscures an under-acknowledged consensus between those who support PAS and those who oppose it. Drawing insights from personalism, this essay situates PAS within larger moral obligations of solidarity with the dying and their caregivers. The contributions of Roman Catholic personalism relocate debates over PAS and allow us to harness shared moral impulses.

This article contributes to the emerging intersectional analyses of religious studies and disability studies by conceptualizing counterprivates specific to religious spaces. To accomplish this task, we investigate the ways in which persons with disabilities, both physical and cognitive, engender counterprivate spaces within Evangelical and Mormon churches. Specifically, we posit that those with disabilities constitute a counterprivate within evangelical communities through theological incongruence and within Mormon spaces through the ways in which counterprivates inform counterpublics. Throughout this paper, we elucidate Mormon and (...) Evangelical spaces as a means of investigating the heterogeneity of private, religious spaces often unrecognized by scholarship. (shrink)

One hundred years ago the expression "God is dead" was first used by Nietzsche. Now, Nietzsche was reared in a christian home, but at the university he decided there was no god.Now, this philosophy began to pervade German thought. And I believe that history is going to say that this philosophy … contributed to a religious, moral and intellectual vacuum, and into that vacuum came Nazism and the concept of the super race that produced Hitler and the second World War.Now, (...) if we in America reject the idea of god and all that that means, we're going to have a vacuum in which either a fascist type or a communist type of ideology is going to come in … that could eventually lead, in my opinion, to anarchy and chaos.The... (shrink)